Failure to Replicate a Genetic Association May Provide Important Clues About Genetic Architecture

Failure to Replicate a Genetic Association May Provide Important Clues About Genetic Architecture

Replication has become the gold standard for assessing statistical results from genome-wide association studies. Unfortunately this replication requirement may cause real genetic effects to be missed. A real result can fail to replicate for numerous reasons including inadequate sample size or variability in phenotype definitions across independent samples. In genome-wide association studies the...

Continuous visual information may be important after all: a failure to replicate Thomson (1983).

The purpose of the two experiments reported here was to replicate previous research (Thomson, 1983) which suggests that visual information useful in the control of movement persists for up to 8 s after visual occlusion. Contrary to other findings (Thomson, 1980, 1983), little evidence was found for an 8-s visual representation of the environmental layout, indicating there is no substitute for c...

Genetic clues of premature ovarian failure

Small-scale morphological differentiation in a cichlid may provide clues about rapidly diversifying systems

Small-scale morphological differentiation in a cichlid may provide clues about rapidly diversifying systems Rebecca Jordan*, David Howe, Karen Kellogg, Francis Juanes, Jay Stauffer Jr and Eva Garcia-Vazquez Ecology, Evolution, and Natural Resources, Cook College, Rutgers University, New Brunswick, NJ 08901, U.S.A., Environmental Studies, Skidmore College, Saratoga Springs, NY 12866, U.S.A., Nat...

Failure to replicate a genetic signal for sex bias in the steppe migration into central Europe.

Goldberg et al. (1) used genome-wide ancient DNA data (2) from central European Bronze Age (BA) populations and their three ancestral sources of steppe pastoralists (SP), Anatolian farmers (AF), and European hunter-gatherers (HG) to investigate whether the SP migration into central Europe after 5,000 years ago (3, 4) was sex-biased. By estimating a lower proportion of SP ancestry on the X chrom...